The acute effect of trimetazidine on the high frequency fatigue in the isolated Rat diaphragm muscle
Yazarlar (5)
Prof. Dr. Mustafa Emre Çukurova Üniversitesi, Türkiye
Ibrahim Karayaylali
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Mustafa San Çukurova Üniversitesi, Türkiye
Ayşe Demirkazik Çukurova Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK Muğla Sıtkı Koçman Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archives of Pharmacal Research (Q4) | ||
| Dergi ISSN | 0253-6269 Dergi Bilgileri (2004) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2004 |
| Cilt / Sayı / Sayfa | 27 / 6 / 646–652 | DOI | 10.1007/BF02980165 |
| Makale Linki | http://link.springer.com/10.1007/BF02980165 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| The objective of this study was to determine the acute effect of trimetazidine (TMZ) on the pre-fatigue, fatigue and post-fatigue contractile characteristics and tension-frequency relationships of isolated rat diaphragm muscle. Muscle strips were taken from the ventral-costal aspects of the diaphragm muscle of rats killed by decapitation. The muscle strips were suspended in organ baths containing Krebs solution, with a gas mixture of 95% O2 and 5% CO2 at 37°C and pH 7.35-7.45. After determining the thermoregulation and optimum muscle length the muscles were subjected to direct supramaximal stimulation with 0.05 Hz frequency square pulses for periods of 0.5 msec to obtain control values. After adding 5x10p-6 and 5x10p-5 M trimetazidine solution to the respective bath media, the contractile parameters of the muscles were recorded. The contractile parameters were also recorded for both the trimetazidine and tri … |
| Anahtar Kelimeler |
| Fatigue | Isolated rat diaphragm muscle | Isometric contraction | Trimetazidine (TMZ) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 6 |
| Google Scholar | 7 |