Remifentanil induced mechanical responses and membrane potential changes in human umbilical arteries
 
Yazarlar (6)
H. Unlugenc Çukurova Üniversitesi, Türkiye
M. Emre
Çukurova Üniversitesi, Türkiye
C. Demir
Çukurova Üniversitesi, Türkiye
T. Guler
Çukurova Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK Çukurova Üniversitesi, Türkiye
G. Isik
Çukurova Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Acta Anaesthesiologica Scandinavica (Q2)
Dergi ISSN 0001-5172 Dergi Bilgileri (2007)
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 02-2007
Cilt / Sayı / Sayfa 51 / 2 / 244–251 DOI 10.1111/j.1399-6576.2006.01210.x
Makale Linki http://doi.wiley.com/10.1111/j.1399-6576.2006.01210.x
UAK Araştırma Alanları
Biyofizik
Özet
Materials and Methods: Following faculty ethic committee approval, thirty-eight human umbilical arteries were obtained. Contraction-relaxation, membrane potential changes and electrical responses of the HUAs were recorded.Results and Discussions: Remifentanil produced concentration-dependent relaxation in both endothelium-intact and denuded HUA rings. Remifentanil produced a significantly greater relaxation response in intact HUA rings than in denuded HUA ones. In endothelium-intact rings, pretreatment with L-Nitroarginine [N w-NITRO-L-ARGININE (L-NO-ARG) or indomethacin reduced the degree of remifentanil-induced relaxation. Remifentanil (10− 9-10− 6 mol L− 1) produced a transient concentration dependent membrane hyperpolarization which was not reduced by pretreatment with L-NO-ARG or indomethacin. It also produced a small concentration-dependent hyperpolarization in the presence …
Anahtar Kelimeler
Analgesics | Human umbilical arteries | Membrane potentials | Opioid | Potassium channel blockers | Remifentanil | Vasorelaxation
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 4
Scopus 4
Google Scholar 6
Remifentanil induced mechanical responses and membrane potential changes in human umbilical arteries

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