Effects of rosiglitazone on altered electrical left ventricular papillary muscle activities of diabetic rat
Yazarlar (6)
Prof. Dr. Servet KAVAK Çukurova Üniversitesi, Türkiye
Prof. Dr. Mustafa Emre Çukurova Üniversitesi, Türkiye
Tamer Tetiker
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Tuyana Kavak
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Zekeriya Kolcu
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Ismail Günay Çukurova Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Naunyn Schmiedeberg S Archives of Pharmacology (Q2) | ||
| Dergi ISSN | 0028-1298 Dergi Bilgileri (2008) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2008 |
| Cilt / Sayı / Sayfa | 376 / 6 / 415–421 | DOI | 10.1007/s00210-007-0234-y |
| Makale Linki | http://link.springer.com/10.1007/s00210-007-0234-y | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| The action potential configuration of the left ventricular papillary muscle as well as the rosiglitazone-dependent changes in ventricular papillary muscle action potential amplitude were studied, and the duration was studied and compared in both healthy and diabetic rats. In this study, we used four groups: (1) nondiabetic control animals (C), (2) rosiglitazone-treated nondiabetic control animals (C+RSG), (3) diabetic animals (D), and (4) rosiglitazone-treated diabetic animals (D+RSG). Diabetes was induced by a single intravenous (i.v.) injection of streptozotocin (STZ). Conventional microelectrode techniques were applied to record action potentials after the establishment of diabetes (8 weeks after STZ treatment). Resting membrane potential (RMP) was decreased significantly in both RSG-treated C and D rats (from −70.2 ± 0.7 to −63.2 ± 0.7 and from −69.2 ± 0.4 to −61.2 ± 0.4). C+RSG and D+RSG groups … |
| Anahtar Kelimeler |
| Action potential duration | Diabetes mellitus | Insulin resistance | K+ channels | Kv. 1.3 channel | Rosiglitazone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 12 |
| Google Scholar | 14 |