The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats
Yazarlar (6)
Prof. Dr. Servet KAVAK Çukurova Üniversitesi, Türkiye
Prof. Dr. Lokman Ayaz Mersin Üniversitesi, Türkiye
Prof. Dr. Mustafa Emre Çukurova Üniversitesi, Türkiye
Tamer Inal
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Lülüfer Tamer Mersin Üniversitesi, Türkiye
Ismail Günay
Çukurova Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cell Biochemistry and Function (Q4) | ||
| Dergi ISSN | 0263-6484 Dergi Bilgileri (2008) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2008 |
| Cilt / Sayı / Sayfa | 26 / 4 / 478–485 | DOI | 10.1002/cbf.1469 |
| Makale Linki | http://doi.wiley.com/10.1002/cbf.1469 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| We investigated the effect of rosiglitazone (RSG), a high‐affinity ligand for the peroxisome proliferator‐activated receptor gamma which mediates insulin‐sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)‐induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were randomly divided into an untreated control group (C), a C + RSG group which was treated with RSG (4 mg kg−1) two times a day by gavage, a diabetic group (D) that was treated with a single intraperitoneal injection of STZ (45 mgkg−1), D + RSG group which were treated with RSG two times a day by gavage, respectively. Lipid profiles, HbA1c and blood glucose levels in the circulation and malondialdehyde (MDA) and 3‐nitrotyrosine (3‐NT) levels in left ventricular muscle were measured. Treatment of D rats with RSG resulted in a time‐dependent decrease in blood glucose. We found that the lipid … |
| Anahtar Kelimeler |
| 3-nitrotyrosine | Diabetes mellitus | Malondialdehyde | Oxidative stress | Rosiglitazone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 23 |
| Scopus | 26 |
| Google Scholar | 28 |