Deterioration of Bone Quality by Streptozotocin STZ Induced Type 2 Diabetes Mellitus in Rats
Yazarlar (5)
Nurten Erdal
Mersin Üniversitesi, Türkiye
Mersin Üniversitesi, Türkiye
Dr. Öğr. Üyesi Serkan Gürgül Mersin Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK Van Yüzüncü Yıl Üniversitesi, Türkiye
Altan Yildiz
Mersin Üniversitesi, Türkiye
Mersin Üniversitesi, Türkiye
Prof. Dr. Mustafa Emre Çukurova Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biological Trace Element Research (Q3) | ||
| Dergi ISSN | 0163-4984 Dergi Bilgileri (2011) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2011 |
| Cilt / Sayı / Sayfa | 140 / 3 / 342–353 | DOI | 10.1007/s12011-010-8703-4 |
| Makale Linki | http://link.springer.com/10.1007/s12011-010-8703-4 | ||
| UAK Araştırma Alanları |
Biyofizik
|
||
| Özet |
| Patients with diabetes mellitus (DM) have various skeletal disorders and bone quality can be impaired in DM leading to fractures. Wistar albino male rats (270–300 g; n = 16) were assigned randomly to nondiabetic and diabetic rats (single dose intravenous injection of 45 mg/kg streptozotocin). All rats in each group were perpetuated for 8 weeks, and blood glucose levels as well as body weights were measured once weekly. Biomechanical measurements were performed at the mid-diaphysis of the left femur with tensile test. Extrinsic and intrinsic properties were measured or calculated. Bone mineral density (BMD) was also evaluated and measured by dual-energy X-ray absorptiometry. Cross-sectional area of the femoral shaft was evaluated by computerized tomography. Blood glucose levels in diabetic rats were significantly increased compared to that of the nondiabetic rats, while the body and femur weights … |
| Anahtar Kelimeler |
| Bone biomechanics | Bone quality | Bone strength | Rat | Type 2 diabetes mellitus |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 24 |
| Scopus | 25 |
| Google Scholar | 46 |