Effects of Rosiglitazone with Insulin Combination Therapy on Oxidative Stress and Lipid Profile in Left Ventricular Muscles of Diabetic Rats
Yazarlar (3)
Prof. Dr. Servet KAVAK Van Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Lokman Ayaz Mersin Üniversitesi, Türkiye
Prof. Dr. Mustafa Emre Çukurova Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Experimental Diabetes Research (Q2) | ||
| Dergi ISSN | 1687-5214 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2012 |
| Cilt / Sayı / Sayfa | 2012 / 1 / 1–7 | DOI | 10.1155/2012/905683 |
| Makale Linki | http://www.hindawi.com/journals/jdr/2012/905683/ | ||
| UAK Araştırma Alanları |
Sosyal, Beşeri ve İdari Bilimler
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| Özet |
| Purpose. In this study, we tested the hypothesis that rosiglitazone (RSG) with insulin is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation. Methods and Materials. Male albino Wistar rats were randomly divided into an untreated control group (C), a diabetic group (D) that was treated with a single intraperitoneal injection of streptozotocin (45 mgkg−1), and rosiglitazone group that was treated with RSG twice daily by gavage and insulin once daily by subcutaneous injection (group B). HbA1c and blood glucose levels in the circulation and malondialdehyde and 3‐nitrotyrosine levels in left ventricular muscle were measured. Result. Treatment of D rats with group B resulted in a time‐dependent decrease in blood glucose. We found that the lipid profile and HbA1c levels in group B reached the control group D rat values at the end of the treatment period. There … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 4 |
| Google Scholar | 8 |