Effects of Insulin on Altered Mechanical and Electrical Papillary Muscle Activities of Diabetic Rats
Yazarlar (1)
Prof. Dr. Servet KAVAK İzmir Bakırçay Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Membrane Biology (Q3) | ||
| Dergi ISSN | 0022-2631 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Cilt / Sayı / Sayfa | 246 / 1 / 31–37 | DOI | 10.1007/s00232-012-9499-2 |
| Makale Linki | http://link.springer.com/10.1007/s00232-012-9499-2 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| Since insulin compounds can restore some metabolic parameters and lipid profile alterations of the diabetic rat heart, we investigated whether these beneficial effects extend to diabetic rat cardiac dysfunctions. Twenty-four male Wistar albino rats, 6 months of age with an average body weight of 250–320 g, were divided randomly into three groups, each consisting of eight rats: control-group (C) rats were fed with standard rat nutrient and water; diabetic-group (D) rats were treated with a single intramuscular injection of streptozotocin (STZ, 45 mg/kg), dissolved in 0.01 M sodium citrate, pH adjusted to 4.5; and insulin-treated diabetic group (D + INS) rats were treated with subcutaneous injections of 1 IU/l insulin (INS) twice a day after a single intramuscular injection of STZ (45 mg/kg). Treatment of D rats with INS caused a time-dependent decrease in blood glucose. We found that the lipid profile and HbA1c levels in the … |
| Anahtar Kelimeler |
| Contraction force | Diabetes mellitus | Electrophysiology | Insulin | Papillary muscle |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 6 |