Investigation of the Hepatoprotective Effects of Sesame Sesamum indicum L in Carbon Tetrachloride Induced Liver Toxicity
Yazarlar (8)
Nureddin Cengiz Van Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK Van Yüzüncü Yıl Üniversitesi, Türkiye
Ali Güzel State Hospital, Türkiye
Prof. Dr. Hanefi Özbek T.C. Sağlık Bakanlığı,, Türkiye
Doç. Dr. Hava Bektaş Van Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Aydin Him Ondokuz Mayis Üniversitesi, Türkiye
Ender Erdoǧan Selçuk Üniversitesi, Türkiye
Ragib Balahoroǧlu
Selçuk Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Membrane Biology (Q3) | ||
| Dergi ISSN | 0022-2631 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Cilt / Sayı / Sayfa | 246 / 1 / 1–6 | DOI | 10.1007/s00232-012-9494-7 |
| Makale Linki | http://link.springer.com/10.1007/s00232-012-9494-7 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| More than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl4). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl4-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl4. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl4 group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from … |
| Anahtar Kelimeler |
| ALP | ALT | AST | Carbon tetrachloride | Histology | Liver | Rat | Sesame | Sesamum indicum L. |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Scopus | 25 |
| Google Scholar | 33 |