Effects of Theophylline with Methylprednisolone Combination Therapy on Biomechanics and Histopathology in Diaphragm Muscles of Rats
Yazarlar (6)
Doç. Dr. Nureddin Yuzkat Van Yüzüncü Yıl Üniversitesi, Türkiye
Ismail Kati
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yasemin Isik İzmir Kâtip Çelebi Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK Muğla Sıtkı Koçman Üniversitesi, Türkiye
Doç. Dr. Ugur Goktas Van Yüzüncü Yıl Üniversitesi, Türkiye
Nurettin Cengiz Sakarya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Inflammation (Q3) | ||
| Dergi ISSN | 0360-3997 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2016 |
| Cilt / Sayı / Sayfa | 39 / 5 / 1635–1641 | DOI | 10.1007/s10753-016-0397-0 |
| Makale Linki | http://link.springer.com/10.1007/s10753-016-0397-0 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| The purpose of this study was to investigate the effects of theophylline and methylprednisolone on the mechanical response and histopathology of hemidiaphragm muscle in rats. In the current study, we aimed to investigate the effects of theophylline and methylprednisolone, which are frequently used in clinics and which have different effects on the respiratory system and on the biomechanics and histopathology of the diaphragm muscle. The study included four groups of rats. Group T received 1 mg/kg of intraperitoneal theophylline, group M received 2 mg/kg of intraperitoneal methylprednisolone, group TM received 1 mg/kg of intraperitoneal theophylline plus 2 mg/kg of intraperitoneal methylprednisolone, and group K received of 1 mL intraperitoneal isotonic solution (of 0.9 % NaCl). The medications were continued for 7 days in each group. The rats underwent cervical dislocation under anesthesia on the eighth … |
| Anahtar Kelimeler |
| biomechanical parameters | diaphragm muscle | histopathology | methylprednisolone | theophylline |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 1 |
| Google Scholar | 6 |