Effect of short term treatment with levosimendan on oxidative stress in renal tissues of rats
Yazarlar (8)
İlhan Gecit
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK Van Yüzüncü Yıl Üniversitesi, Türkiye
Mehmet Bilgehan Yüksel
Mus State Hospital, Türkiye
Mus State Hospital, Türkiye
Halil Basel Bezmiâlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Hava Bektaş Van Yüzüncü Yıl Üniversitesi, Türkiye
Hasan Ali Gümrükçüoğlu Van Yüzüncü Yıl Üniversitesi, Türkiye
İsmail Meral Van Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Halit Demir Van Yüzüncü Yıl Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Toxicology and Industrial Health (Q2) | ||
| Dergi ISSN | 0748-2337 Dergi Bilgileri (2014) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2014 |
| Cilt / Sayı / Sayfa | 30 / 1 / 47–51 | DOI | 10.1177/0748233712451773 |
| Makale Linki | http://tih.sagepub.com/cgi/doi/10.1177/0748233712451773 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| The aim of this study is to evaluate the influences of short-term treatment with levosimendan (chemical formula: C14H12N6O) on oxidative stress and some trace element levels in renal tissues of healthy rats. A total of 20 male Wistar-albino rats were randomly divided into two groups, each consisting of 10 rats. Animals in the first group were not treated with levosimendan and served as control. Animals in the second group were injected intraperitoneally with 12 µg/kg levosimendan and served as levosimendan group. Animals in both the groups were killed 3 days after the treatment, and their kidneys were harvested for the determination of tissue oxidant/antioxidant statues and trace element levels in renal tissues. The tissue malondialdehyde level was significantly (p < 0.001) lower in levosimendan group than in controls. The protective enzyme activities such as superoxide dismutase, catalase, and glutathione … |
| Anahtar Kelimeler |
| Levosimendan | oxidant–antioxidant level | oxidative stress | rat kidney | trace element level |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Scopus | 22 |
| Google Scholar | 36 |