Protective Effects of Thymoquinone on Doxorubicin-induced Lipid Peroxidation and Antioxidant Enzyme Levels in Rat Peripheral Tissues
Yazarlar (6)
Prof. Dr. Deniz Akpınar Muğla Sıtkı Koçman Üniversitesi, Türkiye
Tanju Mercan Muğla Sıtkı Koçman Üniversitesi, Türkiye
Prof. Dr. Halit Demir Van Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Semir Özdemir Akdeniz University, Faculty Of Medicine, Türkiye
Prof. Dr. Canan Demir Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK İzmir Bakırçay Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Pakistan Veterinary Journal (Q1) | ||
| Dergi ISSN | 0253-8318 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2023 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2023 |
| Cilt / Sayı / Sayfa | 43 / 4 / 651–658 | DOI | 10.29261/pakvetj/2023.070 |
| Makale Linki | http://dx.doi.org/10.29261/pakvetj/2023.070 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| We aimed to investigate the effects of thymoquinone (TQ) against Doxorubicin (DOX)-induced toxicity in liver, lung, kidney, testes, diaphragm and stomach tissues of rats. Healthy twenty-eight Wistar albino male rats aged three months, were divided into four groups, each containing seven animals: Group 1: Control (C group); the rats were injected intraperitoneally with saline 5 times every other day and given by gavage to the vehicle solution Group 2 (T group): Rats treated with thymoquinone (10mg/kg given by gavage), Group 3 (D group): Rats treated with doxorubicin were injected intraperitoneally (3mg/kg) and Group 4 (DT group): Rats treated with doxorubicin (injected intraperitoneally with 3mg/kg DOX) and thymoquinone (10mg/kg given by gavage). Group 2 (T group): TQ (10mg/kg) was administered by gavage at 24-hour intervals for 4 weeks. Saline (ip) was injected to rats 5 times every other day. Group 3 (D group): The rats were injected with 3 mg/kg DOX (ip) 5 times every other day. In addition, vehicle solution was administered by gavage at 24-h intervals for 4 weeks. Group 4 (DT group): Rats were injected with 3mg/kg DOX (ip) 5 times every other day. TQ (10mg/kg) was administered by gavage at 24-h intervals for 4 weeks. At the end of the experiment, the animals were euthanized with sodium pentobarbital (50 mg/kg) and their lung, liver, stomach, kidney, diaphragm and testicular tissues were removed for the measurement of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels. It was observed that DOX administration (in group D) increased lipid peroxidation and … |
| Anahtar Kelimeler |
| Antioxidant Enzymes | Doxorubicin | Lipid Peroxidation | Peripheral Tissues | Rat | Thymoquinone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Scopus | 23 |
| Google Scholar | 25 |