Short term levosimendan treatment protects rat testes against oxidativestress
Yazarlar (7)
M. B. Yuksel
Mus State Hospital, Türkiye
Mus State Hospital, Türkiye
Prof. Dr. Servet KAVAK Van Yüzüncü Yıl Üniversitesi, Türkiye
I. Gecit
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
H. Basel
University Hospital, Türkiye
University Hospital, Türkiye
H. A. Gümrükçüoǧlu
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
H. Demir
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
I. Meral
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Brazilian Journal of Medical and Biological Research (Q3) | ||
| Dergi ISSN | 0100-879X Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2012 |
| Cilt / Sayı / Sayfa | 45 / 8 / 716–720 | DOI | 10.1590/S0100-879X2012007500075 |
| Makale Linki | https://www.scielo.br/j/bjmbr/a/LNHTJ4VtQ8RdJVcng3NMSjJ/?lang=en&format=pdf | ||
| UAK Araştırma Alanları |
Sosyal, Beşeri ve İdari Bilimler
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| Özet |
| The objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 µg/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes. |
| Anahtar Kelimeler |
| GSH-Px | Levosimendan | MDA | Oxidative stress | Rat testes | Reactive oxygen species | SOD |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 16 |
| Google Scholar | 19 |