Analysis of the Influences of Short-Term Levosimendan Exposure on Oxidant/Antioxidant Status and Trace-Element Levels in the Physiological Status of the Thoracic Aorta of Rats
Yazarlar (9)
Prof. Dr. Cemalettin Aydın Bezmiâlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yasin Ay Ege Üniversitesi, Türkiye
Prof. Dr. Halil Başel Lokman Hekim Üniversitesi, Türkiye
Prof. Dr. Servet KAVAK İzmir Bakırçay Üniversitesi, Türkiye
Dr. Öğr. Üyesi Bekir İnan Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Hava Bektaş Van Yüzüncü Yıl Üniversitesi, Türkiye
Hasan Ali Gümrükçüoğlu
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
Hasan Ekim Yozgat Bozok Üniversitesi, Türkiye
Prof. Dr. Halit Demir Van Yüzüncü Yıl Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Membrane Biology (Q2) | ||
| Dergi ISSN | 0022-2631 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 29-07-2012 |
| Cilt / Sayı / Sayfa | 245 / 12 / 827–832 | DOI | 10.1007/s00232-012-9489-4 |
| Makale Linki | http://dx.doi.org/10.1007/s00232-012-9489-4 | ||
| UAK Araştırma Alanları |
Biyofizik
|
||
| Özet |
| The objective of this study was to evaluate the effect of levosimendan (chemical formula C14H12N6O) exposure on oxidant/antioxidant status and trace-element levels in the thoracic aorta of rats. Eighteen male Wistar albino rats were randomly divided into two groups of eight animals each. Group 1 was not exposed to levosimendan and served as a control. Levosimendan (12 μg/kg) diluted in 10 ml 0.5 % dextrose was administered intraperitoneally to group 2. Animals of both groups were killed after 3 days, and their thoracic aortae were harvested for determination of changes in tissue oxidant/antioxidant status and trace-element levels. The animals in both groups were killed 72 h after levosimendan exposure, and thoracic aortae were harvested for determination of the lipid peroxidation product MDA and antioxidant GSH levels and the activities of antioxidant enzymes such as SOD, GSH-Px and CAT. It was found … |
| Anahtar Kelimeler |
| Antioxidant | Free radical | GSH-Px | Levosimendan | MDA | Oxidant | Oxidative stress | Rat | SOD | Thoracic aorta |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 4 |