Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats
Yazarlar (8)
İlhan Geçit Türkiye
Prof. Dr. Servet KAVAK Türkiye
Mehmet Bilgehan Yüksel
Türkiye
Türkiye
Prof. Dr. Halil Başel Türkiye
Doç. Dr. Hava Bektaş Van Yüzüncü Yıl Üniversitesi, Türkiye
Hasan Ali Gümrükçüoğlu
Türkiye
Türkiye
İsmail Meral Türkiye
Prof. Dr. Halit Demir Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Toxicology and Industrial Health (Q3) | ||
| Dergi ISSN | 0748-2337 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2012 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 21-06-2012 |
| Cilt / Sayı / Sayfa | 30 / 1 / 47–51 | DOI | 10.1177/0748233712451773 |
| Makale Linki | http://dx.doi.org/10.1177/0748233712451773 | ||
| UAK Araştırma Alanları |
Biyofizik
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| Özet |
| The aim of this study is to evaluate the influences of short-term treatment with levosimendan (chemical formula: C14H12N6O) on oxidative stress and some trace element levels in renal tissues of healthy rats. A total of 20 male Wistar-albino rats were randomly divided into two groups, each consisting of 10 rats. Animals in the first group were not treated with levosimendan and served as control. Animals in the second group were injected intraperitoneally with 12 µg/kg levosimendan and served as levosimendan group. Animals in both the groups were killed 3 days after the treatment, and their kidneys were harvested for the determination of tissue oxidant/antioxidant statues and trace element levels in renal tissues. The tissue malondialdehyde level was significantly ( p < 0.001) lower in levosimendan group than in controls. The protective enzyme activities such as superoxide dismutase, catalase, and glutathione peroxidase and antioxidant glutathione level were significantly ( p < 0.001) higher in levosimendan group than in controls. It was concluded that levosimendan reduced oxidative stress by avoiding lipid peroxidation and production of reactive oxygen species, and overactivating and/or increasing the protective antioxidant enzyme levels in renal tissues of rats. It is supposed that this experimental study provides beneficial data for clinicians in the management of renal tissue damage related to obstruction and/or ischemia. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |